From Unofficial Handbook of the Virtue Universe
Characters who have departed some sort of containment or confinement, in antagonistic circumstances. They might have escaped from a mad science experiment, arcane ritual, prison (justly incarcerated or nefariously trapped), a military or militia, or an alien event. Maybe they are fleeing an alternate reality.
One thing is likely: someone wants to find these characters, and put them back in whatever situation they escaped!